Everyone an incredible woman named Barbara Arietta lives here in Pacifica. On 9-11-2001 she got the devastating news that her son had been killed on the flight that originated in Boston and crashed into one of the World Trade Center towers. She was seen by grief counselors. Then she got the biggest and happiest surprise of her life. Her son called her. He told her that he was fine. He told her that he had decided not to take the flight.
Life takes us in many strange directions and wonderful discoveries. It never turns out the way we thought it would.
Wednesday, September 11, 2019
September 11 In My Life
Madame
President:
Your morning briefing..23 years ago today
I was on a Greyhound bus. It started in Houston, went to San Antonio, onto El
Paso, Phoenix, Indio, California and Los Angeles. My bus ticket went all the
way to San Jose, California. I was tempted to get off in Los Angeles because I
knew that city. I stayed on the bus. I had to find a newspaper reporter named
Gary Webb. I knew that my ex-wife Maria was there and hoped that the kids were
with her. As the bus pulled into San Jose around three in the afternoon, I had
an old-fashioned transistor radio. I listened to a Portuguese music station. I
had no job and less than $200 in my pocket. I was 47-years old and starting my
life over. On September 11, 1998, I was having dinner at the Crowne Plaza
Mexican Restaurant in the Willow Glen section of San Jose. Six US Marshals
arrested me for contempt of court for failing to obey a judge's order. This
cost me 6 months in jail. On September 11, 2001, we had the attacks on New York
City and Washington, DC. As I watched on television, I was sure that a major
war was starting. I called my stepson Pedro and wife Elena to make sure that
they were OK.
Today at 17:00 I go to the memorial service
for Reverend Fernando Carvalho. He was the man who died on his 58th birthday at
the pool last Friday morning. He leaves behind a wife, two children, and four
grandchildren. The late President John F. Kennedy had a favorite saying as
follows:
"Life is always unfair."
Tuesday, September 10, 2019
Monday, September 9, 2019
Sunday, September 8, 2019
A Great Man Runs For Presidenr
Former S.C. congressman Mark Sanford announces Republican primary challenge against Trump
https://wapo.st/2LAKdpi
Tuesday, September 3, 2019
Can Low-Gravity Kill Cancer Cells?
Can low gravity kill cancer?
We’ve been sending humans to space for more than half a century now, but there is still so much to learn about how a low-gravity environment impacts our physiology. An Australian scientist has been looking into such matters through simulation studies here on Earth, and with early indications that space can kill off the majority of cancer cells without the need for drugs, is now preparing to launch his experiments toward the International Space Station for further investigation.
There are quite a few studies that have been completed or are ongoing at the International Space Station that explore the effects of low-gravity on living organisms and human physiology.
NASA has previously studied cellular changes of mice and mussels on the ISS to gain new insights into the human immune system and looked into how the microgravity environment can lead to vision impairment. The agency’s twin study, meanwhile, comparing the biology of an identical twin who spent almost a year at the ISS with the other who did not, continues to be one of the more intriguing examples.
But the intricacies of how cancer cells behave in the microgravity environment remains largely unexplored. Biomedical engineer Joshua Chou has been conducting experiments in his laboratory at the University of Technology Sydney to advance our understanding of this, using a micro-gravity simulator to observe how cancer cells respond and the potential reasons why.
“Prior to this research, most focus has been on the genetic expression of cancer under microgravity,” Chou explains to New Atlas. “But no one has looked at the mechanisms, and the strategy of how we are approaching this is to identify the sensing receptors in the cancer, in hope of tricking them.”
Chou and his student Anthony Kirollos exposed ovarian, breast, nose and lung cancer cells to the micro-gravity simulator for a 24-hour period, and found that it caused 80 to 90 percent of them to die, as first reported by the ABC. The scientists believe this is because the lack of gravitational force on the cells influences how they communicate with one another and makes them unable to sense their surroundings, something they call mechanical unloading.
“I have to clarify that microgravity does affect other cells, like bone cells, that is why astronauts lose bone,” Chou tells us. “But having said that, the different tissues and organs in the body respond differently, and it’s just that we found bone and cancers are super sensitive to the effects of microgravity.”
Why this mechanical unloading effect hits cancer cells harder than most is one of the questions Chou hopes to shed some light on when he launches his experiment for the ISS next year. In the first Australian research mission to the ISS, the cells will be packed into a device smaller than a tissue box and studied within the micro-gravity environment for a period of one week.
“Twenty-four hours before launch, we will introduce the cells into microfluidic devices, they will go up to the ISS and the experiment will be carried out for seven days, but won’t return until after 28 days at the ISS,” Chou says. “Then of course we will do analysis upon its return. But we also designed technologies to study them while they are alive on the ISS.”
Sending cancer patients to space for treatment certainly seems a fanciful idea, and Chou isn’t looking to change that through his inventive line of investigation. The hope is that the experiments can shed light on the specific receptors and sensors behind the mechanical unloading effect on cancer cells, so scientists can design drugs that mimic the same effects here on Earth.
"I see what we are developing on working in conjunction with existing therapies and not replacing anything,“ Chou says. “What we hope is that it will increase efficiency of current drugs to give the patient an added advantage by disrupting the normal function of the cancer. Because if the cells can't 'function as a team' then it becomes easier to kill them.”
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